Pilot Research Projects

Pilot Research Grant Recipients

Dr. Valerae Lewis, of the MD Anderson Center at the University of Texas


PROJECT: Assessing the Efficacy of IL-11 Targeted Treatment for the Treatment of Osteosarcoma

Dr. Lewis graduated from Harvard Medical School in 1993.  She completed her general surgery residency at Beth Israel Medical Center in Boston, Massachusetts in 1994.  From 1994-98 she conducted her Orthopaedic Surgery residency at Harvard Combined Orthpaedic Residency Program in Boston.  Dr. Lewis also completed a fellowship in Musculoskeletal Oncology at The University of Chicago.  Currently she is  the Associate Professor of Surgery, Ad-Interim Chief of the Department of Orthopaedic Oncology at the University of Texas,  MD Anderson Cancer Center.

Dr. Lewis investigates the linking of chemotherapeutic agents to molecules that hone to the tumor, and the tumor alone, which has the potential to deliver therapy without the systemic side effects now seen with chemotherapy.  Targeted therapy has the potential to not only increase the therapeutic options, but make those options more tolerable.



Dr. Bruno Fuchs, of The University of Zurick

PROJECT: Assessment of Intraarterial Chemotherapy in an Osteosarcoma Mouse Model of Spontaneous Metastasis

Dr. Fuchs graduated from the University of Zurich, Switzerland Medical School in 1992.  He completed his medical residency in Orthopaedic Surgery at the Universities of Zurich, Bern and Lausanne.  From 1998-00 he completed an Orthopedic Oncology Fellowship at the Mayo Clinic in Rochester, MN.  He also attended Mayo Graduate School in 2004 and received a PhD in Tumor Biology.  Since 2004, Dr. Fuchs has been the Director of Orthopedic Research at the University of Zurich.

Dr. Fuchs researches a method of intraarterial (IA) infusion using microcatheterisation of the epigastric artery of mice which is developed in their lab.  This method allows assessing advantages of IA over intravenous chemotherapy in an established mouse model of osteosarcoma provoked by intratibial inoculation of low and high metastatic osteosarcoma cell lines.  The local response to IA Cisplatin as well as its effect on lung metastases will be investigated.


Dr. Nicole Ehrhart, VMD of CSU Flint Animal Cancer Center

Project: Isolated Limb Perfusion Using Samarium for Canine Osteosaracoma: Proof of Concept

Dr. Nicole Ehrhart graduated from the University of Pennsylvania College of Veterinary Medicine in 1990. She completed an internship in general medicine and surgery at the Animal Medical Center in New York City and was accepted into a surgery residency at Colorado State University in 1991. She completed her surgical residency and Masters degree in Clinical Sciences in 1994 and became Board Certified in Surgery in 1995 during the first year of a 2 year postdoctoral Fellowship in Surgical Oncology and Orthopedic Research. Following completion of her Fellowship she was recruited in 1996 to the University of Illinois College of Biomedical Sciences as an Assistant Professor in Surgical Oncology where she remained for 6 years. In 2002, concurrent with the opening of the new Flint Animal Cancer Center at Colorado State University College of Veterinary Medicine and Biomedical Sciences, she returned to Colorado to join the faculty as a Professor of Surgical Oncology. She holds joint faculty appointments in the School of Biomedical Engineering and the Cell and Molecular Biology Programs, is a member of the Gates Regenerative Medicine Center at the University of Colorado and is a University of Colorado Cancer Center member.

Her project focus is in the isolated limb perfusion using Samarium for Canine Osteosarcoma.



Dr. Francis Eshun, M.D. of Cincinnati Children's Hospital Medical Center

PROJECT: Biologic Local Control in Xenograft Models of Pediatric Bone Tumors Using Ocolytic Herpes and anti-VEGF Antibodies

Dr. Eshun graduated from the Univerisity of Ghana medical School in 1996.  He spent one year as an intern at the Korle-bu teaching hospital in Ghana in pediatrics and surgery departments.  He worked at the ER department of the same hospital for a year as a senior house officer and then went to the United Kingdom where he worked for 4 years in pediatrics.  He came to the U.S., and finished residency training in pediatrics at Lincoln Hospital which he completed in 2005.  He joined Cincinnati Children's Hospital Medical Center in July, 2005 as a subspecialty postdoctoral fellow in pediatric hematology/oncology.

Dr. Eshun's project investigates biologic local control in xenograft models of pediatric bone tumors using Oncolytic Herpes Virus and anti-VEGF Antibodies.